The Archive

Scientific Insights and Industry Perspectives

A Tale of Two Karelias: How a Divided Land Birthed the Old Friend Hypothesis

The remarkable story of how one divided landscape changed the course of modern immunology

August 6, 2026

Archive Materials

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Dirt is Good: Why Nature is One of Our First Immune Teachers

Exploring the science behind why safe exposure to nature may be one of the oldest forms of immune education

From Missing Microbes to Old Friends: The Next Chapter of the Microbiome Revolution

How the microbiome revolution is expanding beyond the gut to the environmental microbes that shaped human health

Childhood Microbial Experience

Childhood microbial experience, immunoregulation, inflammation and adult susceptibility to psychosocial stressors and depression in rich and poor countries

The Hygiene Hypothesis – Learning From but Not Living in the Past

The epidemiological basis for the Hygiene Hypothesis became apparent long before the Hygiene Hypothesis was postulated.

Environmental Biodiversity, Human Microbiota, and Allergy are Interrelated

Rapidly declining biodiversity may be a contributing factor to another global megatrend—the rapidly increasing prevalence of allergies and other chronic inflammatory diseases among urban populations worldwide.